The Scripps Research Translational Institute, formerly named Scripps Translational Science Institute (STSI), was founded in 2007 with one essential aim—to individualize healthcare by leveraging the remarkable progress being made in human genomics and combining it with the power of wireless digital technologies. By recognizing that every patient is unique, individualized healthcare tailors medical care to the patient, taking into account not only a person’s genes, but also their environment, behavior and lifestyle. Bringing together basic scientists and clinical investigators, the Translational Institute fosters highly collaborative multidisciplinary research with the greatest potential to transform the practice of healthcare and improve human health.